Prebiotic Evolution: ATP Energy

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The Average Molecular Knowledge Per Bit

The results arrived at here are very important. Because G3PD is a medium sized ancient enzyme, there is good reason to believe that the average knowledge per bit calculated for it, can be applied to other enzymes.

   That is if one wants to calculate the molecular knowledge of a particular enzyme evolving in the primordial soup the calculation is now trivial. If the enzyme in question contains 1,000 amino acids, simply multiple 1,000 x 3.16 bits per amino acid = 3,160 bits. The odds of the protein evolving in the soup are 1 in 2 3160 or 1 in 1.8 x 10951.

   The accuracy of the number so calculated will be very good for enzymes that show about the same level of conservation as G3PD, but it might be very poor for enzymes that are more strongly conserved. Likewise, with the genetic code, the knowledge in a 1,000 amino acid enzyme is predicted to be 1,000 amino acids x 0.57 bits per amino acid = 570 bits.

   To test this method, the molecular knowledge of the first enzyme in adenine synthesis should contain 290 bits of knowledge with the genetic code (510 amino acids x 0.57 bits per amino acid = 290). A direct calculation of knowledge using the same techniques that were applied to G3PD results in 303 bits. This is only a 4% error. So at least in this case, the procedure does seem to work quite well.

   Perhaps an even better approach is to scale results of the above calculation by the number of columns that contain knowledge. This technique may prove useful when more resolution is required. For the purpose of this book, the number of amino acids multiplied by either 0.57 or 3.16 will be adequate.
                

next: Odds of ATP Synthesis Evolving

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Navigation Menu Chapter 14


Chapter 14: Information Required for ATP Synthesis

       Oxidation Releases Energy
       ATP Created By Proton Gradients
       ATP Synthesis with a Single Enzyme
       G3PD Knowledge
       Molecular Knowledge in G3PD
        Correction for Primordial Soup
        Odds of ATP and Adenine Evolution
       Does this Approach Generate False Knowledge
       ATP Synthase

PDF: ATP Synthesis (2 Mb)

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